Clinical features and prognosis of childhood acute myeloid leukemia with myelodysplasia-related changes / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 271-278, 2021.
Article
in Zh
| WPRIM
| ID: wpr-879845
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To study the clinical features and prognosis of childhood acute myeloid leukemia with myelodysplasia-related changes (AML-MRC).@*METHODS@#A retrospective analysis was performed on the medical data of 14 children who were diagnosed with AML-MRC from June 2014 to March 2020, including clinical features, laboratory examination results, and prognosis.@*RESULTS@#Among the 14 children with AML-MRC, there were 9 boys and 5 girls, with a median age of 11 years (range: 1-17 years), a median leukocyte count of 8.3×10@*CONCLUSIONS@#Childhood AML-MRC is often observed in boys, and AML-M5 is the most common type based on FAB classification. Such children tend to have a poor prognosis. HSCT is expected to improve the poor prognosis of children with AML-MRC. However due to the small number of cases, it is necessary to increase the number of cases for further observation.
Full text:
1
Index:
WPRIM
Main subject:
Prognosis
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Myelodysplastic Syndromes
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Leukemia, Myeloid, Acute
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Retrospective Studies
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Hematopoietic Stem Cell Transplantation
Type of study:
Observational_studies
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Prognostic_studies
Limits:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2021
Type:
Article