Protective effect of transplantation of human oligodendrocyte precursor cells in a rat model of white matter injury / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 410-415, 2021.
Article
in Zh
| WPRIM
| ID: wpr-879868
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To study the effect of human oligodendrocyte precursor cell (hOPC) transplantation in the treatment of white matter injury (WMI).@*METHODS@#Neonatal rats were randomly divided into a sham-operation group, a model group, and a transplantation group (@*RESULTS@#The place navigation test using the Morris water maze showed that the model group had a significantly longer escape latency than the sham-operation group, and compared with the model group, the transplantation group had a significant reduction in escape latency (@*CONCLUSIONS@#Intrathecal hOPC transplantation may alleviate neurological injury and promote remyelination in a rat model of WMI.
Full text:
1
Index:
WPRIM
Main subject:
Oligodendroglia
/
White Matter
/
Oligodendrocyte Precursor Cells
/
Animals, Newborn
/
Myelin Sheath
Limits:
Animals
/
Humans
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2021
Type:
Article