Research progress on transient receptor potential melastatin 2 channel in nervous system diseases / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 267-276, 2021.
Article
in En
| WPRIM
| ID: wpr-879970
Responsible library:
WPRO
ABSTRACT
Transient receptor potential M2 (TRPM2) ion channel is a non-selective cationic channel that can permeate calcium ions, and plays an important role in neuroinflammation, ischemic reperfusion brain injury, neurodegenerative disease, neuropathic pain, epilepsy and other neurological diseases. In ischemic reperfusion brain injury, TRPM2 mediates neuronal death by modulating the different subunits of glutamate N-methyl-D-aspartic acid receptor in response to calcium/zinc signal. In Alzheimer's disease, TRPM2 is activated by reactive oxygen species generated by β-amyloid peptide to form a malignant positive feedback loop that induces neuronal death and is involved in the pathological process of glial cells by promoting inflammatory response and oxidative stress. In epilepsy, the TRPM2-knockout alleviates epilepsy induced neuronal degeneration by inhibiting autophagy and apoptosis related proteins. The roles of TRPM2 channel in the pathogenesis of various central nervous system diseases and its potential drug development and clinical application prospects are summarized in this review.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Neuroglia
/
Amyloid beta-Peptides
/
Neurodegenerative Diseases
/
Transient Receptor Potential Channels
/
TRPM Cation Channels
Limits:
Humans
Language:
En
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2021
Type:
Article