Effect of pretreatment with acetaminophen on withdrawal movements associated with injection of rocuronium: a prospective, randomized, double-blind, placebo controlled study / 대한마취과학회지
Korean Journal of Anesthesiology
; : 13-16, 2010.
Article
in En
| WPRIM
| ID: wpr-88003
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Withdrawal movement during rocuronium injection is a common, unresolved adverse effect. We aimed to investigate the effect of IV acetaminophen pretreatment on withdrawal movement during rocuronium injection.METHODS:
This study enrolled 120 American Society of Anesthesiologists (ASA) I-II patients undergoing general anesthesia. They were randomly assigned to three treatment groups. After occluding venous drainage using a tourniquet on the upper arm, the saline group received 5 ml of 0.9% sodium chloride solution, the lidocaine group received 40 mg of lidocaine, and the acetaminophen group received 50 mg of acetaminophen. During injection of pretreatment drug, pain was assessed on a four-point scale. The tourniquet was released after 120 seconds and anesthesia was performed using thiopental sodium 5 mg/kg followed by rocuronium 0.6 mg/kg. The withdrawal movement was graded on a four-point scale in a double-blind manner.RESULTS:
The incidence of pain on pretreatment injection in saline, lidocaine, and acetaminophen groups was 7.7%, 5.1%, and 2.5%, respectively. The incidence of withdrawal movements was 77.5% in saline group, 32.5% in lidocaine group, and 37.5% in acetaminophen group (P < 0.05).CONCLUSIONS:
Acetaminophen and lidocaine reduced the incidence of withdrawal movement after rocuronium injection compared with saline.Key words
Full text:
1
Index:
WPRIM
Main subject:
Arm
/
Thiopental
/
Tourniquets
/
Sodium Chloride
/
Drainage
/
Incidence
/
Prospective Studies
/
Androstanols
/
Anesthesia
/
Anesthesia, General
Type of study:
Clinical_trials
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Korean Journal of Anesthesiology
Year:
2010
Type:
Article