Mechanism of the Notch signaling pathway in enhancing the efficacy of chemotherapy drugs in osteosarcoma / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1234-1240, 2020.
Article
in English
| WPRIM
| ID: wpr-880591
ABSTRACT
Osteosarcoma is the most common malignant tumors of bone. Since 1970s, researchers had used chemotherapy drugs to treat osteosarcoma. However, multidrug resistance is a major adverse reaction that affects the efficacy of chemotherapy drugs, leading to the reduced survival rate of osteosarcoma patients. The Notch signaling pathway plays an important role in osteosarcoma proliferation, which affects tumor resistance by reducing intracellular drug accumulation, regulating epithelial-mesenchymal transition, dysregulating microRNA, disrupting the expression of apoptosis genes, and regulating tumor stem cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bone Neoplasms
/
Pharmaceutical Preparations
/
Signal Transduction
/
Osteosarcoma
/
Cell Line, Tumor
/
Cell Proliferation
/
Receptors, Notch
Limits:
Humans
Language:
English
Journal:
Journal of Central South University(Medical Sciences)
Year:
2020
Type:
Article
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