Association between single nucleotide polymorphisms of tropoelastin gene and aortic dissection / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 458-466, 2021.
Article
in English
| WPRIM
| ID: wpr-880682
ABSTRACT
OBJECTIVES@#To evaluate the relation between single nucleotide polymorphisms (SNPs) of tropoelastin gene and aortic dissection (AD) via identifying SNPs in the tropoelastin gene, and to detect the level of tropoelastin mRNA, elastin and elastic fibers.@*METHODS@#The specimens of the AD group (@*RESULTS@#Seven SNP loci of the tropoelastin gene were detected in these samples. Among them, 5 SNP loci were polymorphic. The frequency of 3 SNP loci[rs2071307 (G/A), rs34945509 (C/T) and rs17855988 (G/C)] was significantly different between the AD group and the control group (all @*CONCLUSIONS@#The polymorphisms of rs2071307 (G/A), rs34945509 (C/T), and rs17855988(G/C) in the tropoelastin gene may eventually affect the synthesis of elastic fibers and they may play an important role in the occurrence of AD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Elastin
/
Tropoelastin
/
Polymorphism, Single Nucleotide
/
Elastic Tissue
/
Aortic Dissection
Limits:
Humans
Language:
English
Journal:
Journal of Central South University(Medical Sciences)
Year:
2021
Type:
Article
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