Discovery of novel diarylamides as orally active diuretics targeting urea transporters
Acta Pharmaceutica Sinica B
; (6): 181-202, 2021.
Article
in En
| WPRIM
| ID: wpr-881132
Responsible library:
WPRO
ABSTRACT
Urea transporters (UT) play a vital role in the mechanism of urine concentration and are recognized as novel targets for the development of salt-sparing diuretics. Thus, UT inhibitors are promising for development as novel diuretics. In the present study, a novel UT inhibitor with a diarylamide scaffold was discovered by high-throughput screening. Optimization of the inhibitor led to the identification of a promising preclinical candidate,
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WPRIM
Language:
En
Journal:
Acta Pharmaceutica Sinica B
Year:
2021
Type:
Article