Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially
Acta Pharmaceutica Sinica B
; (6): 727-737, 2021.
Article
in En
| WPRIM
| ID: wpr-881165
Responsible library:
WPRO
ABSTRACT
The constitutive androstane receptor (CAR, NR3I1) belongs to nuclear receptor superfamily. It was reported that CAR agonist TCPOBOP induces hepatomegaly but the underlying mechanism remains largely unknown. Yes-associated protein (YAP) is a potent regulator of organ size. The aim of this study is to explore the role of YAP in CAR activation-induced hepatomegaly and liver regeneration. TCPOBOP-induced CAR activation on hepatomegaly and liver regeneration was evaluated in wild-type (WT) mice, liver-specific YAP-deficient mice, and partial hepatectomy (PHx) mice. The results demonstrate that TCPOBOP can increase the liver-to-body weight ratio in wild-type mice and PHx mice. Hepatocytes enlargement around central vein (CV) area was observed, meanwhile hepatocytes proliferation was promoted as evidenced by the increased number of KI67
Full text:
1
Index:
WPRIM
Language:
En
Journal:
Acta Pharmaceutica Sinica B
Year:
2021
Type:
Article