Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators

Shaoyong LU; Yingyi CHEN; Jiacheng WEI; Mingzhu ZHAO; Duan NI; Xinheng HE; Jian ZHANG.

Acta Pharmaceutica Sinica B ; (6): 1355-1361, 2021.

Article in En | WPRIM | ID: wpr-881204

Responsible library: WPRO

ABSTRACT

The recent discovery of activator compounds binding to an allosteric site on the NAD

Key words

ADPR, ADP-ribose; Allosteric driver; Allosteric mechanisms; Allosteric sites; Drug design

Full text: 1 Index: WPRIM Language: En Journal: Acta Pharmaceutica Sinica B Year: 2021 Type: Article

Full text: 1 Index: WPRIM Language: En Journal: Acta Pharmaceutica Sinica B Year: 2021 Type: Article