A prospective observational study on the risk of contrast-induced nephropathy among patients undergoing fundus fluorescein angiography
Philippine Journal of Ophthalmology
; : 70-76, 2020.
Article
in En
| WPRIM
| ID: wpr-886293
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ABSTRACT
@#OBJECTIVE:
To determine the incidence of contrast-induced nephropathy (CIN) among patients undergoing fundus fluorescein angiography (FFA)METHODS:
One hundred fifty-nine (159) patients from the Ophthalmology out-patient department were enrolled in this prospective, observational study. Serum creatinine (SCr) and estimated glomerular filtration rate (eGFR) were measured within 7 days before and 48 to 72 hours after FFA. Subjects were stratified into low-, intermediate-, and high-risk groups for developing CIN according to baseline eGFR. CIN was defined by an increase in SCr by more than 25% or by 0.5 mg/dL within 72 hours of intravascular administration of contrast media. The incidence of CIN, changes in SCr levels, and changes in eGFR were analyzed.RESULTS:
Of the 144 subjects who completed the study, 106 (73.6%) were females, 105 (72.9 %) were diabetics, and 57 (39.6%) had elevated baseline SCr. Four (4 or 2.8%) patients developed CIN after FFA, all of whom had normal baseline SCr and were stratified as low-risks. Overall, there were no significant changes in the means of SCr (1.18 ± 0.56 vs 1.16 ± 0.52, p = 0.13) and eGFR (64.53 ± 26.05 vs 64.94 ± 24.88, p = 0.64) before and after FFA. In the low-risk group, the means of SCr and eGFR remained unchanged after FFA (p = 0.06 and p = 0.15, respectively). In the intermediate-risk group, no significant change was appreciated in SCr levels (p = 0.07) however a significant improvement in eGFR (p = 0.006) was seen. Interestingly, a significant decrease in SCr levels (p = 0.004) as well as a significant improvement in eGFR (p = 0.02) was noted after FFA in the high-risk group.CONCLUSION:
The incidence of CIN among patients undergoing FFA in our cohort was 2.8%. There was no prolonged or serious worsening of renal function based on SCr and eGFR before and after FFA overall, and among low-, moderate-, and high-risk groups.Key words
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Index:
WPRIM
Main subject:
Fluorescein Angiography
/
Incidence
/
Contrast Media
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Creatinine
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Drug-Related Side Effects and Adverse Reactions
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Acute Kidney Injury
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Glomerular Filtration Rate
Type of study:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
Language:
En
Journal:
Philippine Journal of Ophthalmology
Year:
2020
Type:
Article