Progress in Research on the Novel Tumor Marker circRNA / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 435-444, 2021.
Article
in Zh
| WPRIM
| ID: wpr-887877
Responsible library:
WPRO
ABSTRACT
Circular RNA(circRNA)is a novel type of endogenous non-coding RNA.Most circRNAs act as microRNA(miRNA)sponges to regulate the expression of functional genes.In addition,some circRNAs can be translated and interact with RNA-binding proteins to perform biological functions.The expression of circRNAs is prevalent in tissues and body fluids,and their abnormal expression is related to tumor progression.circRNAs are stable even under the treatment of RNase R because of their circular conformation.As circRNAs have construct stability,wide variety,specific regulation of tumor progression and high expression in body fluids,it is potential for circRNAs to serve as candidate diagnostic,prognostic and therapeutic targets.However,the knowledge about circRNAs remains poor.In addition to the not completely resolved functions and generation mechanisms of circRNAs,the annotations of circRNAs are also waiting for expanding.Here,we review the generation mechanisms,biological functions,and application of circRNAs in tumor research,aiming to provide integrated information for the future research.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Prognosis
/
Biomarkers, Tumor
/
MicroRNAs
/
RNA, Circular
Type of study:
Prognostic_studies
Language:
Zh
Journal:
Acta Academiae Medicinae Sinicae
Year:
2021
Type:
Article