Opposite Modulatory Effects of Crataegus aronia Aqueous Extract on Platelet Aggregation in Rats / 中国结合医学杂志
Chinese journal of integrative medicine
; (12): 696-704, 2021.
Article
in En
| WPRIM
| ID: wpr-888660
Responsible library:
WPRO
ABSTRACT
OBJECTIVES@#To reveal the mechanisms behind the dual effects of Crataegus aronia (C. aronia) aqueous extract on platelet aggregation by focusing on function, regulation, expression, and signaling of platelets P@*METHODS@#Adult male Wistar rats (120 ± 10 g) were classified as control received the vehicle, C. aronia (200 mg/kg), and C. aronia (2,000 mg/kg)-treated rats. After treatments for consecutive 7 days, hematological and molecular experiments were conducted to detect alterations in platelet aggregation, thromboxane B2 (THXB2) and intracellular reactive oxygen species (ROS) content; protein levels of P@*RESULTS@#At a concentration of 200 mg/kg, C. aronia inhibited platelet aggregation through multiple interconnected mechanisms including downregulation P@*CONCLUSION@#Oral administration of C. aronia at low dose inhibits platelet aggregation by reducing THXB2 release, expression of P-selectin and activating cAMP and Akt signaling through two major mechanisms including downregulation of P
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WPRIM
Language:
En
Journal:
Chinese journal of integrative medicine
Year:
2021
Type:
Article