Identification and characterization of a novel elastase inhibitor from Hirudinaria manillensis / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 540-544, 2021.
Article
in En
| WPRIM
| ID: wpr-888783
Responsible library:
WPRO
ABSTRACT
A large number of protease inhibitors have been found from leeches, which are essential in various physiological and biological processes. In the curret study, a novel elastase inhibitor was purified and characterized from the leech of Hirudinaria manillensis, which was named HMEI-A. Primary structure analysis showed that HMEI-A belonged to a new family of proteins. HMEI-A exerted inhibitory effects on elastase and showed potent abilities to inhibit elastase with an inhibition constant (K
Key words
Full text:
1
Index:
WPRIM
Main subject:
Protease Inhibitors
/
Pancreatic Elastase
/
Proteins
/
Amino Acid Sequence
/
Leeches
Limits:
Animals
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2021
Type:
Article