Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice
Acta Pharmaceutica Sinica B
; (6): 1541-1554, 2021.
Article
in En
| WPRIM
| ID: wpr-888819
Responsible library:
WPRO
ABSTRACT
Obesity and its associated complications are highly related to a current public health crisis around the world. A growing body of evidence has indicated that G-protein coupled bile acid (BA) receptor TGR5 (also known as Gpbar-1) is a potential drug target to treat obesity and associated metabolic disorders. We have identified notoginsenoside Ft1 (Ft1) from
Full text:
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Index:
WPRIM
Type of study:
Prognostic_studies
Language:
En
Journal:
Acta Pharmaceutica Sinica B
Year:
2021
Type:
Article