Research progress and prospects of adipose stem cells combined with hydrogel materials in tissue engineering / 国际生物医学工程杂志

ABSTRACT

Tissue engineering refers to the combination of cells, biological materials and bioreactors to construct and develop three-dimensional artificial tissues and organs, which are ultimately used to enhance, repair or replace damaged or diseased tissues. Adipose stem cells(ADSCs) are derived from adipose tissue, have multi-directional differentiation potential, can secrete a variety of growth factors, and have the advantages of wide sources, simple acquisition, small trauma, and rapid expansion, making it an ideal seed cell in tissue engineering. Hydrogel is a kind of three-dimensional polymer network material that contains a lot of water. It has excellent biocompatibility, good elasticity, predictable degradation rate and adjustable mechanical properties. These advantages make hydrogel an excellent biomedical material. In recent years, the application of ADSCs combined with hydrogel materials in tissue engineering has received widespread attention, and its related research covers skin, fat, bone, cartilage, muscle, heart, nerve tissue engineering and other fields. In this review paper, the research progress of adipose-derived stem cells combined with hydrogel materials in tissue engineering was reviewed, and its future prospects were put forward.