Research progress of ubiquitin-specific peptidases in tumorigenesis and development / 国际外科学杂志
International Journal of Surgery
;
(12): 774-777, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-907522
ABSTRACT
Protein ubiquitination is one of the important mechanisms regulating protein stability and activity under physiological condition. Among them, E1/E2/E3 ligases and deubiquitination enzyme play an important regulatory role in the process of protein ubiquitination, while deubiquitination may induce the occurrence of tumors, asthma and other diseases. Ubiquitin-specific peptidases, as the main members of the deubiquitination enzyme family, have been proved to be closely related to the occurrence and development of tumors, among which some ubiquitin-specific peptidases have been used as new targets for anti-tumor therapy. Therefore, this study aims to briefly review the regulatory mechanisms of ubiquitin-specific peptidases in the process of tumor genesis and development, which will provide more research directions for tumor therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Surgery
Year:
2021
Type:
Article
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