Research on the anti-lung cancer effects of targeted Neddylation modifying pathway and its inhibitor MLN4924 and its mechanism / 国际肿瘤学杂志
Journal of International Oncology
; (12): 564-567, 2021.
Article
in Zh
| WPRIM
| ID: wpr-907581
Responsible library:
WPRO
ABSTRACT
Neddylation is overactivated in lung cancer, which promotes the development of lung cancer by activating its downstream CRL ubiquitin ligase and promoting the CRL tumor-suppressor protein substrate degradation. MLN4924, a small molecule inhibitor of Neddylation, plays an anti-lung cancer role by inducing cell cycle arrest, apoptosis and senescence. Furthermore, targeting the key enzymes of Neddylation and their substrates, Cullin family proteins, can inhibit the development of lung cancer.
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Journal of International Oncology
Year:
2021
Type:
Article