The therapeutics and management of cryptococcus-related immune reconstitution inflammatory syndrome in AIDS patients / 中华临床感染病杂志
Chinese Journal of Clinical Infectious Diseases
; (6): 222-227, 2021.
Article
in Zh
| WPRIM
| ID: wpr-910886
Responsible library:
WPRO
ABSTRACT
Acquired immune deficiency syndrome (AIDS) can cause various opportunistic infections clinically due to severe defects in the body’s cellular immune function. Cryptococcosis is a common serious opportunistic infection in AIDS patients. With the promotion and popularization of high activity antiretroviral therapy (HAART) programs worldwide, the mortality rate of AIDS-related cryptococcosis has been significantly decreased. After initiating antiviral therapy, some patients experienced recurrence and aggravation of clinical symptoms during anti-cryptococcal treatment. The body has an inflammatory response to the excessive immune regulation of cryptococcal antigens, which is called cryptococcus-related immune reconstitution inflammatory syndrome (C-IRIS). C-IRIS seriously affects the quality of life and prognosis of patients. This article reviews the clinical features, pathogenesis and the latest treatment and management strategies of C-IRIS in AIDS patients.
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Clinical Infectious Diseases
Year:
2021
Type:
Article