Advances in the regulation of type Ⅰ CRISPR system on biofilm formation and antibiotic resistance / 中华检验医学杂志

ABSTRACT

In recent years, bacterial antibiotic resistance is becoming a huge threaten for human health. It′s getting even more serious after biofilm formation. In addition to physical and chemical factors such as barrier function and microenvironmental changes, the regulation of some genes in biofilm also specifically improves the level of antibiotic resistance. There might be a common regulatory mechanism between antibiotic resistance and the ability of biofilm formation. Type Ⅰ clustered regularly interspaced short palindromic repeats (CRISPR) system can affect the acquisition and spread of antibiotic resistance. The effect varies with species, evolution process and environmental pressure. Recently, it has been reported that type Ⅰ CRISPR system could not only regulate biofilm formation, but could also participate in the interaction between bacteriophages and biofilm. It might become a breakthrough point in the study of phage therapy. This article reviews the situation of antibiotic resistance in recent years, the new progress of biofilm-specific antibiotic resistance, and the effects of type Ⅰ CRISPR system on biofilm formation and antibiotic resistance, so as to provide new ideas for the prevention and treatment of bacterial infection.