Effect of vitamin E in nonalcoholic fatty liver disease with metabolic syndrome: A propensity score-matched cohort study
Clinical and Molecular Hepatology
; : 379-386, 2015.
Article
in En
| WPRIM
| ID: wpr-91725
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS: Vitamin E improves the biochemical profiles and liver histology in nonalcoholic steatohepatitis, but the role of vitamin E is not clearly defined in the management of nonalcoholic fatty liver disease (NAFLD) which includes both simple steatosis and steatohepatitis. Co-morbid metabolic syndrome increases the probability of steatohepatitis in NAFLD. In this study, we aimed to determine the short-term effects of vitamin E and off-treatment durability of response in a propensity-score matched cohort of NAFLD patients with metabolic syndrome. METHODS: A retrospective cohort was constructed by retrieving 526 consecutive NAFLD patients from the electronic medical record data warehouse of a tertiary referral hospital in South Korea. Among them, 335 patients (63.7%) had metabolic syndrome and were eligible for vitamin E therapy. In order to assess the effect of vitamin E, propensity score matching was used by matching covariates between control patients (n=250) and patients who received vitamin E (n=85). RESULTS: The PS-matched vitamin E group (n=58) and control group (n=58) exhibited similar baseline metabolic profiles. After 6 months of vitamin E therapy, the mean ALT levels decreased significantly compared to PS-matched control (P<0.01). The changes in metabolic profiles (body weight, lipid and glucose levels) did not differ between control and vitamin E groups during the study period. CONCLUSIONS: Short-term vitamin E treatment significantly reduces ALT levels in NAFLD patients with metabolic syndrome, but metabolic profiles are not affected by vitamin E.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Aspartate Aminotransferases
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Vitamin E
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Body Weight
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Retrospective Studies
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Cohort Studies
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Metabolic Syndrome
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Alanine Transaminase
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Propensity Score
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Republic of Korea
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Non-alcoholic Fatty Liver Disease
Type of study:
Etiology_studies
/
Incidence_studies
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Observational_studies
Limits:
Adult
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Aged
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Female
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Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
Clinical and Molecular Hepatology
Year:
2015
Type:
Article