Advances in the release mechanisms of bluetongue virus / 生物工程学报
Chinese Journal of Biotechnology
; (12): 3179-3189, 2021.
Article
in Zh
| WPRIM
| ID: wpr-921415
Responsible library:
WPRO
ABSTRACT
Bluetongue virus (BTV) causes Bluetongue (BT) of ruminants vectored by culicoides midges. It is also a classic model for studying the release mechanism of non-enveloped virus. This review begins with the infection and assembly of BTV, then summarizes the advances of different ways of releasing BTV. This includes BTV-induced autophagy and the release as extracellular vesicles via multivesicular bodies, BTV-induced apoptosis and the lytic release, as well as different pathways of release through budding via plasma membrane. The regulatory mechanisms of NS3 which is a key non-structural protein during the release of BTV are also discussed, providing a basis for further understanding the molecular mechanisms underpinning the infection, proliferation and release of BTV.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Sheep
/
Ceratopogonidae
/
Viral Nonstructural Proteins
/
Bluetongue
/
Bluetongue virus
Limits:
Animals
Language:
Zh
Journal:
Chinese Journal of Biotechnology
Year:
2021
Type:
Article