Complanatoside A and complanatoside B in rats administered with raw and salt-processed Astragali Complanati Semen: a pharmacokinetics study / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 5953-5957, 2021.
Article
in Zh
| WPRIM
| ID: wpr-921718
Responsible library:
WPRO
ABSTRACT
An UPLC-MS/MS method was developed to simultaneously determine complanatoside A and complanatoside B in rat plasma with rutin as the internal standard and applied to examine the effect of salt-processing on pharmacokinetics of these two flavonoid glycosides. The pharmacokinetic parameters were estimated using DAS 3.2.6 and subjected to independent sample t-test with SPSS 23.0. No significant difference in T_(max) of complanatoside B was observed between the raw and processed groups; however, in the processed group, C_(max) and AUC_(0-12 h) of complanatoside B increased obviously(P<0.05), while MRT_(0-12 h) decreased from(3.34±0.44) h to(1.81±0.36) h(P<0.05). C_(max) [(14.72±11.13) μg·L~(-1)] and MRT_(0-24) [(3.93±0.26) h] of complanatoside A in the raw group were statistically different from those [(35.64±21.99) μg·L~(-1),(1.43±0.24) h] in the processed group(P<0.05). As a result, salt-processing can facilitate the in vivo adsorption and accelerate the excretion of complanatoside A and complanatoside B.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Semen
/
Chromatography, High Pressure Liquid
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Chromatography, Liquid
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Astragalus Plant
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Tandem Mass Spectrometry
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Glycosides
Limits:
Animals
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2021
Type:
Article