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From bulk, single-cell to spatial RNA sequencing / 国际口腔科学杂志·英文版
Article in En | WPRIM | ID: wpr-922464
Responsible library: WPRO
ABSTRACT
RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a more complete genetic picture than DNA sequencing. This most widely used technology in genomics tool box has evolved from classic bulk RNA sequencing (RNAseq), popular single cell RNA sequencing (scRNAseq) to newly emerged spatial RNA sequencing (spRNAseq). Bulk RNAseq studies average global gene expression, scRNAseq investigates single cell RNA biology up to 20,000 individual cells simultaneously, while spRNAseq has ability to dissect RNA activities spatially, representing next generation of RNA sequencing. This article highlights these technologies, characteristic features and suitable applications in precision oncology.
Subject(s)
Full text: 1 Index: WPRIM Main subject: Sequence Analysis, RNA / Precision Medicine / Exome Sequencing / Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: International Journal of Oral Science Year: 2021 Type: Article
Full text: 1 Index: WPRIM Main subject: Sequence Analysis, RNA / Precision Medicine / Exome Sequencing / Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: International Journal of Oral Science Year: 2021 Type: Article