Role of dipeptidyl peptidase-4 inhibitors in new-onset diabetes after transplantation
The Korean Journal of Internal Medicine
; : 759-770, 2015.
Article
in En
| WPRIM
| ID: wpr-92367
Responsible library:
WPRO
ABSTRACT
Despite strict pre- and post-transplantation screening, the incidence of new-onset diabetes after transplantation (NODAT) remains as high as 60%. This complication affects the risk of cardiovascular events and patient and graft survival rates. Thus, reducing the impact of NODAT could improve overall transplant success. The pathogenesis of NODAT is multifactorial, and both modifiable and nonmodifiable risk factors have been implicated. Monitoring and controlling the blood glucose profile, implementing multidisciplinary care, performing lifestyle modifications, using a modified immunosuppressive regimen, administering anti-metabolite agents, and taking a conventional antidiabetic approach may diminish the incidence of NODAT. In addition to these preventive strategies, inhibition of dipeptidyl peptidase-4 (DPP4) by the gliptin family of drugs has recently gained considerable interest as therapy for type 2 diabetes mellitus and NODAT. This review focuses on the role of DPP4 inhibitors and discusses recent literature regarding management of NODAT.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Blood Glucose
/
Risk Factors
/
Organ Transplantation
/
Treatment Outcome
/
Risk Assessment
/
Dipeptidyl Peptidase 4
/
Diabetes Mellitus
/
Dipeptidyl-Peptidase IV Inhibitors
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
The Korean Journal of Internal Medicine
Year:
2015
Type:
Article