Blood-retina barrier dysfunction in experimental autoimmune uveitis: the pathogenesis and therapeutic targets / 대한해부학회지
Anatomy & Cell Biology
;
: 20-27, 2022.
Article
in English
| WPRIM
| ID: wpr-925392
ABSTRACT
Experimental autoimmune uveitis (EAU), an animal model of human uveitis, is characterized by infiltration of autoimmune T cells in the uvea as well as in the retina of susceptible animals. EAU is induced by the immunization of uveitogenic antigens, including either retinal soluble-antigen or interphotoreceptor retinoid-binding proteins, in Lewis rats. The pathogenesis of EAU in rats involves the proliferation of autoimmune T cells in peripheral lymphoid tissues and breakdown of the blood-retinal barrier, primarily in the uvea and retina, finally inducing visual dysfunction. In this review, we describe recent EAU studies to facilitate the design of a therapeutic strategy through the interruption of uveitogenic factors during the course of EAU, which will be helpful for controlling human uveitis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
/
Prognostic study
Language:
English
Journal:
Anatomy & Cell Biology
Year:
2022
Type:
Article
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