Role and mechanism of non-coding RNA in the pathogenesis of acute kidney injury / 生理学报
Acta Physiologica Sinica
; (6): 39-46, 2022.
Article
in Zh
| WPRIM
| ID: wpr-927579
Responsible library:
WPRO
ABSTRACT
Acute kidney injury (AKI) is a common clinical syndrome and an independent risk factor of chronic kidney disease and end-stage renal failure. At present, the treatments of AKI are still very limited and the morbidity and mortality of AKI are rising. Non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs and circular RNAs (circRNAs), are RNAs that are transcribed from the genome, but not translated into proteins. It has been widely reported that ncRNA is involved in AKI caused by ischemia reperfusion injury (IRI), drugs and sepsis through different molecular biological mechanisms, such as apoptosis and oxidative stress response. Therefore, ncRNAs are expected to become a new target for clinical prevention and treatment of AKI and a new biomarker for early warning of the occurrence and prognosis of AKI. Here, the role and mechanism of ncRNA in AKI and the research progress of ncRNA as biomarkers are reviewed.
Full text:
1
Index:
WPRIM
Main subject:
Reperfusion Injury
/
RNA, Untranslated
/
MicroRNAs
/
Acute Kidney Injury
/
RNA, Long Noncoding
/
RNA, Circular
Type of study:
Etiology_studies
/
Prognostic_studies
Limits:
Humans
Language:
Zh
Journal:
Acta Physiologica Sinica
Year:
2022
Type:
Article