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The renal metabolic mechanism of salt sensitive hypertension in Dahl-SS rats / 生理学报
Acta Physiologica Sinica ; (6): 47-58, 2022.
Article in Zh | WPRIM | ID: wpr-927580
Responsible library: WPRO
ABSTRACT
The kidney is one of the main target organs involved in hypertension, and it regulates water and salt metabolism, blood volume and vascular resistance. High salt intake induces salt and water retention, persistent endothelial dysfunction and elevation of blood pressure in salt sensitive individuals. Dahl salt sensitive (Dahl-SS) rats, as a classic animal model for salt sensitive hypertension, have many similar stably inherited physiological characteristics to human with salt sensitive hypertension, such as salt sensitivity, hyperlipidemia, insulin resistance, renal failure, increased urinary protein secretion and low plasma renin activity. Based on renal physiology and biochemistry researches and multi-omics analyses in Dahl-SS rats, this review will summarize the relationship between salt sensitive hypertension and renal redox, NO, amino acids, glucose and lipid metabolism.
Subject(s)
Full text: 1 Index: WPRIM Main subject: Blood Pressure / Sodium Chloride, Dietary / Rats, Inbred Dahl / Hypertension / Kidney Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: Zh Journal: Acta Physiologica Sinica Year: 2022 Type: Article
Full text: 1 Index: WPRIM Main subject: Blood Pressure / Sodium Chloride, Dietary / Rats, Inbred Dahl / Hypertension / Kidney Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: Zh Journal: Acta Physiologica Sinica Year: 2022 Type: Article