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Q-markers of Yuquan Capsules based on serum pharmacochemistry of Chinese medicine / 中国中药杂志
Article in Zh | WPRIM | ID: wpr-928176
Responsible library: WPRO
ABSTRACT
This study analyzed the quality markers(Q-markers) of Yuquan Capsules(YQC) based on serum pharmacochemistry of Chinese medicine and detected the components and metabolites of YQC absorbed into the blood by UPLC-Q-TOF-MS and UNIFI systems. As a result, 32 components of YQC were detected, including 17 prototype components and 15 metabolized components. Among them, 12 prototype components(ginsenoside Rh_2, genistein, formononetin, puerarin, daidzein, schizandrin A, schizandrin B, schizandrin C, schizandrol A, schizandrol B, gomisin D, and ononin) and 12 metabolized components(ginsenoside Rg_1, ginsenoside Rg_2, ginsenoside Rg_3, ginsenoside Ro, 3'-methoxypuerarin, daidzin, astragaloside Ⅱ, astragaloside Ⅳ, glycyrrhizic acid, liquiritigenin, isoliquiritin, and verbascoside) showed inhibitory effects and pharmacological activities against diabetes, and these 24 blood-entering components against diabetes were identified as Q-markers of YQC.
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Full text: 1 Index: WPRIM Main subject: Capsules / Drugs, Chinese Herbal / Chromatography, High Pressure Liquid / Ginsenosides / Serum / Medicine, Chinese Traditional Type of study: Diagnostic_studies Language: Zh Journal: China Journal of Chinese Materia Medica Year: 2022 Type: Article
Full text: 1 Index: WPRIM Main subject: Capsules / Drugs, Chinese Herbal / Chromatography, High Pressure Liquid / Ginsenosides / Serum / Medicine, Chinese Traditional Type of study: Diagnostic_studies Language: Zh Journal: China Journal of Chinese Materia Medica Year: 2022 Type: Article