Identification of a rare platelet-specific antigen HPA-10bw allele among ethnic Han Chinese population in Shandong / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 231-233, 2022.
Article
in Zh
| WPRIM
| ID: wpr-928396
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To study the polymorphism of human platelet antigen (HPA) system 10 among ethnic Han Chinese from Shandong, China so as to supplement the data of platelet donor bank in the region.@*METHODS@#Peripheral blood samples of platelet donors from the region were genotyped for HPA-10 alleles by PCR-sequence specific primer (PCR-SSP) and direct sequencing.@*RESULTS@#Among 1401 donors, a rare heterozygote carrier of HPA-10w (a+b+) was identified, which gave an allelic frequency of approximately 0.035%.@*CONCLUSION@#The detection of rare HPA-10bw antigen allele among ethnic Han Chinese from Shandong is useful for the diagnosis and prevention of neonatal alloimmune thrombocytopenia and post-transfusion purpura in the region.
Full text:
1
Index:
WPRIM
Main subject:
Polymorphism, Genetic
/
Antigens, Human Platelet
/
Asian People
/
Alleles
/
Gene Frequency
/
Genotype
Type of study:
Diagnostic_studies
Limits:
Humans
/
Newborn
Language:
Zh
Journal:
Chinese Journal of Medical Genetics
Year:
2022
Type:
Article