Novel strategies for promoting tumor penetration of anticancer nanomedicines / 药学学报
Acta Pharmaceutica Sinica
; (12): 1758-1770, 2022.
Article
in Zh
| WPRIM
| ID: wpr-929417
Responsible library:
WPRO
ABSTRACT
There is a broad and urgent need for the clinical application of anticancer nanomedicine in tumor therapy, but the complex biological barrier in solid tumors has always been the main obstacle to infiltrating nanomedicine into the tumor. The traditional design of nanomedicine based on enhanced permeability and retention (EPR) effect still has some limitations in tumor permeability, it is urgent to find other design theories. Therefore, this review summarizes two novel strategies, active transcytosis and immune cell-mediated tumor penetration, for promoting tumor penetration of anticancer nanomedicine.
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WPRIM
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2022
Type:
Article