Development and validation of a nomogram for predicting cancer-specific survival in pediatric melanoma / 中华内分泌外科杂志
Chinese Journal of Endocrine Surgery
;
(6): 572-577, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-930262
ABSTRACT
Objective:
To identify prognosis factors and construct a nomogram for the prediction of cancer-specific survival in surgically resected pediatric melanoma.Methods:
A total of 912 patients aged 0-19 years were extracted from the Surveillance, Epidemiology, and SEER database and randomly divided into training cohort (n=640) and validation cohort (n=272) (A ratio of 7030) . Univariable and multivariable cox analysis were used to determine prognostic factors, and these factors were used to construct a nomogram for predicting cancer-specific survival in patients with resected pediatric melanoma. Model performance was evaluated by Harrell’s concordance index (C-index) ,the area under the time-dependent receiver operating characteristic curve (AUC) and calibration plots.Results:
As revealed by the multivariable cox analysis, age, tumor location, ulceration, and lymph node status were all associated with melanoma-specific survival in pediatric patients. On the basis of these factors, a nomogram was constructed. Both the training cohort and the validation cohort had a concordance index of 0.9, which validated the accuracy of our nomogram. The nomogram showed significant discriminative power in both training cohort (3-year AUC 0.87, 5-year AUC 0.88, 10-year AUC 0.85) and validation cohort (3-year AUC 0.87, 5-year AUC 0.87, 10-year AUC 0.89) . Also, the nomogram displayed a good calibration.Conclusions:
These results suggest that the new model has superior predictive performance in predicting cancer-specific survival of pediatric melanoma. This individualized prediction model can provide reference for tailoring treatment and clinical counseling of pediatric melanoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Endocrine Surgery
Year:
2021
Type:
Article
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