Effect of PPOs regimen and antagonist on the outcome of IVF-ET in patients with poor ovarian response / 中华内分泌外科杂志

ABSTRACT

Objective:To compare the effects of high progesterone induced ovulation (PPOs) and antagonist on the outcome of in vitro fertilization embryo transfer (IVF-ET) in patients with poor ovarian response (POR) .Methods:208 POR patients who underwent IVF-ET in our hospital were selected as the research objects, and were randomly divided into observation group and control group according to the random number table method, with 104 cases in each. The observation group were treated with PPOs regimen,while the control group were treated with antagonist regimen.The daily hormone levels of human chorionic gonadotropin (hCG) [follicle stimulating hormone (FSH) , luteinizing hormone (LH) , progesterone (P) , estradiol (E2) ], pregnancy outcome [total amount of gonadotropin (GN) , days of GN administration, number of oocytes retrieved, number of transferred embryos, cycle cancellation rate, oocyte maturation rate] and pregnancy outcomes were compared between the two groups (endometrial thickness on trigger day, number of transferred embryos, implantation rate, pregnancy rate, clinical pregnancy rate, abortion rate, live yield) .Results:The serum LH level in the observation group was significantly lower than that in the control group ( P<0.05) , and there was no difference in HCG hormone levels (FSH, P, E2) between the two groups after treatment ( P>0.05) . The total amount of Gn medication, Gn medication days, and oocyte maturation rate of the observation group after treatment were significantly higher than those of the control group, and the cycle cancellation rate was significantly lower than that of the control group ( P<0.05) ; The number of transferred embryos, embryo implantation rate, and live birth rate in the observation group after treatment were significantly higher than those in the control group, while the abortion rate was significantly lower than that in the control group ( P<0.05) ; There was no significant difference in the endometrial thickness and clinical pregnancy rate on trigger days between the two groups ( P>0.05) . Conclusions:Compared with the antagonist regimen, the PPOS regimen has a more obvious clinical effect in treatment of POR patients. It simplifies the process of ovulation stimulation and enhances the sensitivity of the ovaries to ovulation stimulation drugs. It is safe, convenient, economical and feasible, and is worthy of clinical promotion.