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New insights on aldosterone-producing cell clusters in the pathogenesis of primary aldosteronism / 中华内分泌代谢杂志
Article in Zh | WPRIM | ID: wpr-933386
Responsible library: WPRO
ABSTRACT
Primary aldosteronism(PA) is one of the most common secondary hypertension, the pathogenesis is still not fully understood. Aldosterone synthase(CYP11B2) was thought to be continuously expressed in the zona glomerulosa of the adrenal cortex. In recent years, it is found that there were discontinuous CYP11B2 positive cell clusters in adrenal cortex via immunohistochemical staining, and proposed the concept of aldosterone-producing cell clusters(APCC). Thenceforwarding a growing body of studies suggest that there may be a potential causal link between APCC and PA. This article summarizes the latest studies on APCC and provide an update on the potential role of APCC in the pathogenesis of PA.
Key words
Full text: 1 Index: WPRIM Type of study: Etiology_studies Language: Zh Journal: Chinese Journal of Endocrinology and Metabolism Year: 2022 Type: Article
Full text: 1 Index: WPRIM Type of study: Etiology_studies Language: Zh Journal: Chinese Journal of Endocrinology and Metabolism Year: 2022 Type: Article