Various Oscillation Patterns of Serum Fibroblast Growth Factor 21 Concentrations in Healthy Volunteers
Diabetes & Metabolism Journal
; : 29-36, 2012.
Article
in En
| WPRIM
| ID: wpr-93408
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Fibroblast growth factor 21 (FGF21) was originally identified as a paroxysm proliferator activated receptor-alpha target gene product and is a hormone involved in metabolic regulation. The purpose of this study was to investigate the diurnal variation of serum FGF21 concentration in obese and non-obese healthy volunteers.METHODS:
Blood samples were collected from five non-obese (body mass index [BMI] or =25 kg/m2) healthy young men every 30 to 60 minutes over 24 hours. Serum FGF21 concentrations were determined by radioimmunoassay. Anthropometric parameters, glucose, free fatty acid, insulin, leptin, and cortisol concentrations were also measured.RESULTS:
The serum FGF21 concentrations displayed various individual oscillation patterns. The oscillation frequency ranged between 6 and 12 times per day. The average duration of oscillation was 2.52 hours (range, 1.9 to 3.0 hours). The peaks and troughs of FGF21 oscillation showed no circadian rhythm. However, the oscillation frequency had a diurnal variation and was lower during the light-off period than during the light-on period (2.4 vs. 7.3 times, P or =0.19 ng/mL).CONCLUSION:
Various oscillation patterns in serum FGF21 concentration were observed, and reduced oscillation frequencies were seen during sleep. The oscillation patterns of serum FGF21 concentration suggest that FGF21 may be secreted into systemic circulation in a pulsatile manner. Obesity appeared to affect the amplitude of oscillations of serum FGF21.Key words
Full text:
1
Index:
WPRIM
Main subject:
Hydrocortisone
/
Radioimmunoassay
/
Circadian Rhythm
/
Leptin
/
Fibroblast Growth Factors
/
Fibroblasts
/
Glucose
/
Insulin
/
Obesity
Type of study:
Prognostic_studies
Limits:
Humans
/
Male
Language:
En
Journal:
Diabetes & Metabolism Journal
Year:
2012
Type:
Article