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A Case of Scleroderma-like Cutaneous Lesions Induced by Docetaxel in a Patient with Breast Cancer
Article in En | WPRIM | ID: wpr-93444
Responsible library: WPRO
ABSTRACT
Docetaxel, an anti-microtubule agent, has been reported to show cytotoxic effects in solid tumors. Its toxicities also include neutropenia, alopecia, skin reaction, and fluid retention. In this study, we report on a case of a 57-year-old Korean female who presented with rapidly progressive scleroderma-like cutaneous changes in the upper and lower extremities after administration of docetaxel. Results of the following tests were normal or negative: full blood count, serum urea, creatinine, electrolytes, liver function test, thyroid function test, rheumatoid factor, anti-nuclear antibody, and anti-topoisomerase antibody. No structural abnormalities were noted on esophagogastroduodenoscopy, chest computed tomography, and Doppler ultrasonography. A biopsy of skin from the left calf showed dermal sclerosis. There was no other explanation for the lesion, except a scleroderma-like cutaneous change induced by docetaxel in this Korean female undergoing treatment for breast cancer.
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Full text: 1 Index: WPRIM Main subject: Rheumatoid Factor / Sclerosis / Skin / Thorax / Thyroid Function Tests / Urea / Biopsy / Breast / Breast Neoplasms / Endoscopy, Digestive System Limits: Female / Humans Language: En Journal: Journal of Rheumatic Diseases Year: 2013 Type: Article
Full text: 1 Index: WPRIM Main subject: Rheumatoid Factor / Sclerosis / Skin / Thorax / Thyroid Function Tests / Urea / Biopsy / Breast / Breast Neoplasms / Endoscopy, Digestive System Limits: Female / Humans Language: En Journal: Journal of Rheumatic Diseases Year: 2013 Type: Article