Research progress of epigenetic regulation in the pathogenesis of aluminum exposure / 中华预防医学杂志
Chinese Journal of Preventive Medicine
; (12): 240-244, 2022.
Article
in Zh
| WPRIM
| ID: wpr-935276
Responsible library:
WPRO
ABSTRACT
Aluminum is one of the most abundant elements on earth. Aluminum compounds are widely used in food additives, antacids, cooking utensils and so on. Human exposure to aluminum is mainly through diet and drinking water, while excessive intake of aluminum can accumulate in tissues and cause toxic reactions. In the central nervous system, aluminum exposure is closely related to a series of nervous system diseases such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Epigenetic modification refers to the regulation of gene expression without changing the DNA sequence, and its regulatory disorders can lead to abnormalities and diseases of the central nervous system. This paper describes the regulation of epigenetics and its components, including DNA methylation, histone modification and non-coding RNA, in aluminum-induced neurotoxicity, in order to provide insights into the epigenetic mechanism of aluminum-induced neurotoxicity.
Full text:
1
Index:
WPRIM
Main subject:
DNA Methylation
/
Cooking
/
Epigenesis, Genetic
/
Aluminum
/
Alzheimer Disease
Type of study:
Etiology_studies
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Preventive Medicine
Year:
2022
Type:
Article