Research Progress on Immunomodulatory Activity and Clinical Application of Mesenchymal Stem Cells-Derived Extracellular Vesicles--Review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 955-958, 2022.
Article
in Chinese
| WPRIM
| ID: wpr-939715
ABSTRACT
Mesenchymal stem cells (MSC) have been widely used in tissue regeneration and treatment graft versus host disease (GVHD) and immune diseases due to their self-renewal, multi-differentiation and immunoregulatory potential. However, more and more scholars begin to put weight on the MSC -derived extracellular vesicles (MSC-EV) for its regulation of inflammation and immunity. MSC-EV can activate the relevant signal pathways and regulate the function and biological behaviors of cells via acting on target cells and mediating communication between cells. MSC-EV has important potential clinical applications for its powerful immunomodulatory and hematopoietic regulatory functions. It is considered as a potential therapeutic tool to treat autoimmune diseases and GVHD. This paper reviewed the immunomodulatory activity of MSC-EV as well as the research progress of MSC-EV in hematopoietic stem cell transplantation, and discussed its potential clinical applications in the future.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cell Differentiation
/
Hematopoietic Stem Cell Transplantation
/
Mesenchymal Stem Cell Transplantation
/
Mesenchymal Stem Cells
/
Extracellular Vesicles
/
Graft vs Host Disease
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2022
Type:
Article
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