Your browser doesn't support javascript.
loading
Anti-atherosclerotic effects of perilla oil in rabbits fed a high-cholesterol diet / 한국실험동물학회지
Laboratory Animal Research ; : 171-179, 2016.
Article in En | WPRIM | ID: wpr-94495
Responsible library: WPRO
ABSTRACT
Anti-atherosclerosis effects of perilla oil were investigated, in comparison with lovastatin, in rabbits fed a high-cholesterol diet (HCD). Hypercholesterolemia was induced in rabbits by feeding the HCD containing 0.5% cholesterol and 1% corn oil, and perilla oil (0.1 or 0.3%) was added to the diet containing 0.5% cholesterol for 10 weeks. HCD greatly increased blood total cholesterol and low-density lipoproteins, and caused thick atheromatous plaques, covering 74% of the aortic wall. Hyper-cholesterolemia also induced lipid accumulation in the liver and kidneys, leading to lipid peroxidation. Perilla oil not only attenuated hypercholesterolemia and atheroma formation, but also reduced fat accumulation and lipid peroxidation in hepatic and renal tissues. The results indicate that perilla oil prevents atherosclerosis and fatty liver by controlling lipid metabolism, and that it could be the first choice oil to improve diet-induced metabolic syndrome.
Subject(s)
Key words
Full text: 1 Index: WPRIM Main subject: Corn Oil / Lovastatin / Lipid Peroxidation / Cholesterol / Perilla / Diet / Atherosclerosis / Lipid Metabolism / Fatty Liver / Plaque, Atherosclerotic Limits: Animals Language: En Journal: Laboratory Animal Research Year: 2016 Type: Article
Full text: 1 Index: WPRIM Main subject: Corn Oil / Lovastatin / Lipid Peroxidation / Cholesterol / Perilla / Diet / Atherosclerosis / Lipid Metabolism / Fatty Liver / Plaque, Atherosclerotic Limits: Animals Language: En Journal: Laboratory Animal Research Year: 2016 Type: Article