The Prevalence and Clinical Characteristics of Hepatitis-delta Infection in Korea / 대한간학회지
The Korean Journal of Hepatology
; : 43-50, 2005.
Article
in Ko
| WPRIM
| ID: wpr-94682
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS:
The prevalence of hepatitis delta virus (HDV) infection has been estimated as being approximately 5% among global HBsAg carriers. The anti-delta positive rate in Koreans had been reported as being 0.85% in 1985. While the prevalence of HBV has been decreased from nearly 10% to 5% during the past twenty years, there have been no more studies on the anti-delta prevalence in Koreans. The aim of this study was to estimate the anti-delta prevalence in Koreans and to study the clinical characteristics of anti-delta positive patients in a single center.METHODS:
Serum anti-delta was measured in one hundred ninety four HBsAg-positive patients who were admitted to our hospital from February 2003 to August 2003. We checked the genotypes of the HBV in the anti-delta positive patients. The clinical features of the anti-delta positive patients were compared to those clinical features of the anti-delta negative patients from the aspect of age, gender, mode of transmission, the positivity of HBeAg and serum HBV DNA.RESULTS:
Serum anti-delta was positive in seven patients among the 194 subjects, giving a 3.6% positive rate. Among these seven patients, six had hepatocellular carcinoma (HCC) and the other one had cholangiocarcinoma. All of the anti-delta positive patients had the C genotype of HBV. The anti-delta positive patients showed significantly suppressed HBV DNA replication compared to the anti-delta negative patients.CONCLUSIONS:
In Koreans, anti-delta was positive mainly in HCC patients with an approximate prevalence of 4%, and this rate has not changed much for the past twenty years. HBV DNA replication was suppressed by HDV infection.Key words
Full text:
1
Index:
WPRIM
Main subject:
Hepatitis D
/
English Abstract
/
Hepatitis Delta Virus
/
Hepatitis Antibodies
/
Prevalence
/
Carcinoma, Hepatocellular
/
Hepatitis delta Antigens
/
Korea
/
Liver Neoplasms
Type of study:
Prevalence_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Ko
Journal:
The Korean Journal of Hepatology
Year:
2005
Type:
Article