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Autophagy Regulated by Chinese Medicine Monomers in Embryo Implantation: A Review / 中国实验方剂学杂志
Chinese Journal of Experimental Traditional Medical Formulae ; (24): 253-262, 2023.
Article in Chinese | WPRIM | ID: wpr-953947
ABSTRACT
Embryo implantation is one of the most critical steps in the reproductive process. The failure of embryo implantation to continue development is one of the important reasons leading to infertility. The success of embryo implantation depends on the high receptivity of endometrium and the embryo with implantation ability. Autophagy is a process in which cytoplasmorganelles, and inclusions are absorbed by double-membrane vesicles and transported to lysosomes for degradation and recycling, which is a way to maintain the homeostasis. A large amount of evidence have shown that autophagy plays an important role in all aspects of embryo implantation. Based on this, this paper explored the relationship between autophagy and endometrial receptivity and embryo implantation ability. According to the latest research progress, this paper combed 5 mechanisms (promotion of decidualization of endometrial stromal cells, promotion of apoptosisregulation of hormone levels, coordination of inflammation, and promotion of ovulation) of 14 kinds of Chinese medicine monomers, including emodin, catalpol, paeoniflorin, resveratrolfolic acidzearalenonecurcumin, wogonin, quercetin, chrysin, berberineapigenin, phisetine, and kaempferol, in regulating different links of autophagy intervention in embryo implantation. This paper is expected to provide references and ideas for future Chinese medicine monomers to improve the success rate of embryo implantation.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2023 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2023 Type: Article