Role of Ammonia in the Pathogenesis of Hepatic Encephalopathy (review) / 中国康复理论与实践
Chinese Journal of Rehabilitation Theory and Practice
; (12): 136-139, 2010.
Article
in Zh
| WPRIM
| ID: wpr-959251
Responsible library:
WPRO
ABSTRACT
@#Ammonia toxicity has been generally accepted as one of the classic theories of the pathogenesis of hepatic encephalopathy (HE). Ammonia induces changes in neurological system energy metabolism, oxidative stress, mitochondrial permeability transition (MPT), GABA and Glutamatergic neurotransmission, intracellular signal transduction and Aquaporin 4 (AQP4) expression, astrocyte swelling is another important consequence of ammonia neurotoxicity. This article reviewed the role of these factors in the mechanism of HE and ammonia toxicity.
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Rehabilitation Theory and Practice
Year:
2010
Type:
Article