Efficacy of calcitonin gene-related peptide antagonists in the treatment of acute migraine: A systematic review and meta-analysis
Acta Medica Philippina
;
: 44-51, 2019.
Article
| WPRIM
| ID: wpr-959763
ABSTRACT
Objective:
This study determined the efficacy of calcitonin gene-related peptide (CGRP) antagonists in the treatment of acute migraine.Methods:
Seven randomized, controlled trials were included. Outcome measures used were pain freedom and pain relief two hours after treatment.Results:
The difference in pain freedom 2 hours post-dose significantly favored gepants 140/150 mg (OR=2.39, 95% CI=1.93-2.96, PConclusion:
With regard to pain freedom and pain relief two hours post-dose, CGRP antagonists are more efficacious than placebo in the treatment of acute migraine but there is insufficient evidence to demonstrate superior efficacy of CGRP antagonists over triptans.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pain
/
Tryptamines
/
Calcitonin Gene-Related Peptide
/
Migraine Disorders
Type of study:
Systematic reviews
Limits:
Humans
Journal:
Acta Medica Philippina
Year:
2019
Type:
Article
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