Autoantibody-Mediated Sensory Polyneuropathy Associated with Indolent B-Cell Non-Hodgkin's Lymphoma: A Report of Two Cases
Journal of Clinical Neurology
; : 283-286, 2015.
Article
in En
| WPRIM
| ID: wpr-96073
Responsible library:
WPRO
ABSTRACT
BACKGROUND AND PURPOSE: Abnormalities of the peripheral nervous system occur in 5% of patients with lymphoma. Polyneuropathy has not been described in patients with mantle-cell and marginal-zone B-cell lymphomas. CASE REPORT: Two elderly patients with indolent non-Hodgkin's lymphoma developed a progressive sensory polyneuropathy that was associated with serum autoantibodies directed against asialosyl/sialosyl gangliosides and myelin-associated glycoprotein/sulfated glucuronyl paragloboside, respectively, which are peripheral-nerve antigens. The oligoclonal pattern of these antibodies hinted at a lymphoma-induced immune dysregulation. The neuropathy stabilized clinically during treatment with intravenous immunoglobulin G. B-cell lymphoma was managed with a "watchful waiting" approach. CONCLUSIONS: The concept of antigen-specific, immune-mediated neuropathy associated with slow-growing lymphoma of mature B-cells may be underrecognized. The principle of treating the illness underlying neuropathy may not be always indicated or necessary if risk-benefit and cost-benefit analyses are taken into account.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Polyneuropathies
/
Autoantibodies
/
Lymphoma, Non-Hodgkin
/
Immunoglobulin G
/
B-Lymphocytes
/
Autoimmunity
/
Lymphoma, B-Cell
/
Cost-Benefit Analysis
/
Peripheral Nervous System
/
Gangliosides
Limits:
Aged
/
Humans
Language:
En
Journal:
Journal of Clinical Neurology
Year:
2015
Type:
Article