Demethylchlortetracycline: laboratory and clinical observations in infants and children in the Philippines

ABSTRACT

From our observations in infants and children in the Philippines, DMCT proves to be a useful drug against infections caused by organisms within the spectrum of the tetracyclines. Side reactions are minimal. These consisted mainly of gastrointestinal upset. Both the drop and syrup form produce similar bacteriostatic serum levels which are prolonged for at least 12-13 hours even when the medication is taken after feeding. There is only a slight diffusion of the drug into the cerebrospinal fluid. (Summary)