Research progress on pathogenesis and treatment of drug-resistant epilepsy / 药学学报
Acta Pharmaceutica Sinica
; (12): 581-592, 2023.
Article
in Zh
| WPRIM
| ID: wpr-965636
Responsible library:
WPRO
ABSTRACT
Epilepsy is a chronic nervous system disease, which affects more than 70 million people all over the world. Although more than 30 kinds of antiepileptic drugs (AEDs) have been on the market, about one third of the patients with epilepsy fail to respond to medical treatment, who become drug-resistant epilepsy patients. Identifying the mechanism and developing effective treatment methods for drug-resistant epilepsy have become a hot area in the field of epilepsy research. This review discussed resent advance on the pathogenesis of drug-resistant epilepsy from the transporter hypothesis, neural network hypothesis and target hypothesis, and we also summarized the existing potential treatment methods and research progress of drug-resistant epilepsy, such as surgical resection, deep brain stimulation, ketogenic diet, precise treatment, and traditional Chinese medicine treatment. Our review may provide useful clues for the mechanisms research and clinical treatments of drug-resistant epilepsy.
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2023
Type:
Article