Research progress on T cell glycolytic metabolism in oral lichen planus / 口腔疾病防治
Journal of Prevention and Treatment for Stomatological Diseases
;
(12): 679-684, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-974755
ABSTRACT
@#Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa. The pathogenesis of OLP is still unclear. Immune abnormalities mediated by T cells and related cytokines play a crucial role in the pathogenesis of OLP. In recent years, glycolytic metabolism-related transporters, enzymes and regulators, such as glucose transporter-1 (Glut1), glyceraldehyde 3-phosphate dehydrogenase (GAPDH), lactate dehydrogenase A (LDHA), mammalian target of rapamycin (mTOR) and hypoxia inducible factor-1α (HIF-1a), have attracted an increasing amount of attention in OLP by regulating the proliferation and differentiation of T cells and the secretion of inflammatory factors. It has been shown that 2-deoxy-D-glucose (2-DG) or rapamycin (RAPA) inhibits the glycolytic metabolism of T cells and then inhibits OLP. This article reviews the research progress of glycolytic metabolism-related transporters, enzymes and regulatory factors in OLP in recent years.
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Prevention and Treatment for Stomatological Diseases
Year:
2023
Type:
Article
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