A randomized, comparative study on the efficacy and safety of mangosteen 1% extract gel versus benzoyl peroxide 5% gel in the treatment of mild to moderate acne vulgaris
Journal of the Philippine Dermatological Society
; : 15-23, 2021.
Article
in En
| WPRIM
| ID: wpr-978126
Responsible library:
WPRO
ABSTRACT
Introduction@#Acne vulgaris is a common dermatologic disorder caused by follicular epidermal hyperproliferation, excess se- bum production, inflammation, and Cutibacterium acnes (C. acnes). The mangosteen fruit rind contains large amount of xantho- nes, which has high antimicrobial activity against C. acnes.@*Objectives@#To compare the efficacy and safety of mangosteen 1% extract gel versus benzoyl peroxide (BPO) 5% gel in the treat- ment of mild to moderate acne vulgaris.@*Methods@#A total of 60 participants with mild to moderate acne or a rating of 2 or 3 in the Investigator’s Global Assessment (IGA) for acne were randomized to receive either mangosteen 1% extract gel or BPO 5% gel applied on the face twice daily over an 8-week period. Primary outcomes measured in the study were clinical remission graded as “clear” or “almost clear” (rating of 0 or 1) based on the IGA and any adverse reaction.
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Index:
WPRIM
Main subject:
Benzoyl Peroxide
/
Acne Vulgaris
Language:
En
Journal:
Journal of the Philippine Dermatological Society
Year:
2021
Type:
Article