Arsenic speciation and valence / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2396-2405, 2023.
Article
in Zh
| WPRIM
| ID: wpr-981316
Responsible library:
WPRO
ABSTRACT
As arsenic widely exists in nature and has been used in the pharmaceutical preparations, the traditional Chinese medicine(TCM) with arsenic include realgar(As_2S_2 or As_4S_4), orpiment(As_2S_3), and white arsenic(As_2O_3). Among the above representative medicine, the TCM compound formulas with realgar are utilized extensively. Just in Chinese Pharmacopoeia(2020 edition), there are 37 Chinese patent medicines including realgar. The traditional element analysis focuses on the detection of the total amount of elements, which neglects the study on the speciation and valence of elements. The activity, toxicity, bioavailability, and metabolic pathways of arsenic in vivo are closely related to the existence of its form, and different forms of arsenic have different effects on organisms. Therefore, the study on the speciation and valence of arsenic is of great importance for arsenic-containing TCMs and their compound formulas. This paper reviewed four aspects of the speciation and valence of arsenic, including property, absorption and metabolism, toxicity, and analytical assay.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Arsenic
/
Arsenicals
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Sulfides
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Biological Products
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Drugs, Chinese Herbal
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Arsenic Trioxide
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Medicine, Chinese Traditional
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2023
Type:
Article