Progress in the Study of Spindle Assembly Checkpoint in Lung Cancer / 中国肺癌杂志
Chinese Journal of Lung Cancer
; (12): 310-318, 2023.
Article
in Zh
| WPRIM
| ID: wpr-982161
Responsible library:
WPRO
ABSTRACT
Spindle assembly checkpoint (SAC) is a protective mechanism for cells to undergo accurate mitosis. SAC prevented chromosome segregation when kinetochores were not, or incorrectly attached to microtubules in the anaphase of mitosis, thus avoiding aneuploid chromosomes in daughter cells. Aneuploidy and altered expression of SAC component proteins are common in different cancers, including lung cancer. Therefore, SAC is a potential new target for lung cancer therapy. Five small molecule inhibitors of monopolar spindle 1 (MPS1), an upstream component protein of SAC, have entered clinical trials. This article introduces the biological functions of SAC, summarizes the abnormal expression of SAC component proteins in various cancers and the research progress of MPS1 inhibitors, and expects to provide a reference for the future development of lung cancer therapeutic strategies targeting SAC components.
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Key words
Full text:
1
Index:
WPRIM
Main subject:
Protein Serine-Threonine Kinases
/
Cell Cycle Proteins
/
M Phase Cell Cycle Checkpoints
/
Lung Neoplasms
/
Spindle Apparatus
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Lung Cancer
Year:
2023
Type:
Article