Your browser doesn't support javascript.
loading
Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma / 医学前沿
Frontiers of Medicine ; (4): 240-262, 2023.
Article in En | WPRIM | ID: wpr-982569
Responsible library: WPRO
ABSTRACT
Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities.
Subject(s)
Key words
Full text: 1 Index: WPRIM Main subject: Brain Neoplasms / Neural Stem Cells / Tumor Microenvironment / Oligodendrocyte Precursor Cells / Glioma / Neoplasm Recurrence, Local Limits: Humans Language: En Journal: Frontiers of Medicine Year: 2023 Type: Article
Full text: 1 Index: WPRIM Main subject: Brain Neoplasms / Neural Stem Cells / Tumor Microenvironment / Oligodendrocyte Precursor Cells / Glioma / Neoplasm Recurrence, Local Limits: Humans Language: En Journal: Frontiers of Medicine Year: 2023 Type: Article